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For individuals who tolerate the medication well and may need additional support in managing blood glucose, the dose may be increased to 7.5 mg, 10 mg, 12.5 mg, or a maximum of 15 mg weekly, depending on the healthcare providers recommendations

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Diabetes can cause the nitration of GLP-1 receptors, leading to pericyte dysfunction and loss of cerebrovascular integrity

Additionally, because of the sedentary lifestyle associated with OA, it increases cardiovascular mortality by more than 50%, necessitating its listing in 2018 as a severe disease by the Food and Drug Administration (FDA) 5

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